Hotel LITTLE ITALY INN, 505 WEST GRAPE ST, United states. The Little Italy Inn, downtown San Diego's (Calif. only European style bed and breakfast, is located in the heart of the city's Italian cultural village, just minutes from the vibrant Gaslamp Quarter and a five minute drive from Lindbergh Airport. Guests can walk to restaurants, sidewalk cafes and art boutiques. Getting to San Diego Zoo or SeaWorld is as easy as hopping a trolley, hailing a taxi or reserving a chauffeured bicycle cab.The Little Italy Inn features complimentary continental breakfasts and 22 rooms uniquely decorated with distinctive Victorian designs and décor. Guestrooms include have cable television, high speed Internet access and spa robes. Guestrooms with private baths, whirlpool baths, kitchenettes and courtyard or harbor views are also available.